Identification of HLA-A24 restricted pre-erythrocytic stage specific T-cell epitopes using plasmodium falciparum synthetic peptides: a preliminary study

• Main Authors: Pongsri Tippawangkosol, Thitimonrat Duangchanda, Ratawan Ubalee, Ronnatrai Ruengweerayut, Kenji Hirayama, Kesara Na-Bangchang
• Format: Journal
• Published: 2018
• Subjects: Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=59149092814&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/59909
• Institution: Chiang Mai University

Fourteen (9 amino acids) peptides of Plasmodium falciparum pre-erythrocytic stage antigens, namely, TRAP, CTRP, LSA-1, STARP and MSP-1, restricted to HLA-A24 and specific to T-cell response were identified. The antigen-specific IFN-γ responses of these synthetic peptides in malaria exposed and non-m...