SOX9 transduction increases chondroitin sulfate synthesis in cultured human articular chondrocytes without altering glycosyltransferase and sulfotransferase transcription

• Main Authors: Simon R. Tew, Peraphan Pothacharoen, Theoni Katopodi, Timothy E. Hardingham
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=50949114221&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/60150
• Institution: Chiang Mai University

The transcription factor SOX9 (Sry-type high-mobility-group box 9) is expressed in all chondrocytes and is essential for the expression of aggrecan, which during biosynthesis is substituted with more than 10 times; its weight of CS (chondroitin sulfate) and is secreted by chondrocytes to form the ch...