Inhibitory effects of asiatic acid and CPT-11 on growth of HT-29 cells

• Main Authors: Piyawan Bunpo, Keiko Kataoka, Hideki Arimochi, Haruyuki Nakayama, Tomomi Kuwahara, Usanee Vinitketkumnuen, Yoshinari Ohnishi
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=15544366910&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/62116
• Institution: Chiang Mai University

Asiatic acid is a pentacyclic triterpene contained in medicinal plants. The cytotoxic effect of this compound and its augmentative effect on the anticancer drug irinotecan hydrochloride (CPT-11) were investigated in the human colon adenocarcinoma cell line HT-29. Asiatic acid dose-dependently showed...