Insight into Molecular Determinants of T3 vs T4 Recognition from Mutations in Thyroid Hormone Receptor α and β

• Main Authors: Karn Wejaphikul, Stefan Groeneweg, Yvonne Hilhorst-Hofstee, V. Krishna Chatterjee, Robin P. Peeters, Marcel E. Meima, W. Edward Visser
• Format: Journal
• Published: 2019
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85066479373&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/65365
• Institution: Chiang Mai University

© 2019 Endocrine Society. Context The two major forms of circulating thyroid hormones (THs) are T3 and T4. T3 is regarded as the biologically active hormone because it binds to TH receptors (TRs) with greater affinity than T4. However, it is currently unclear what structural mechanisms underlie this...