The in vitro functional impairment of thyroid hormone receptor alpha 1 isoform mutants is mainly dictated by reduced ligand sensitivity

The in vitro functional impairment of thyroid hormone receptor alpha 1 isoform mutants is mainly dictated by reduced ligand sensitivity

© Mary Ann Liebert, Inc. Background: Thyroid hormone (TH) acts on TH receptors (TRs) and regulates gene transcription by binding of TRs to TH response elements (TREs) in target gene promoters. The transcriptional activity of TRs is modulated by interactions with TR-coregulatory proteins. Mutations i...

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Bibliographic Details
Main Authors: Karn Wejaphikul, Anja L.M. van Gucht, Stefan Groeneweg, W. Edward Visser, Theo J. Visser, Robin P. Peeters, Marcel E. Meima
Format: Journal
Published: 2020
Subjects:
Biochemistry, Genetics and Molecular Biology
Medicine
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85077016490&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/67595
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Institution: Chiang Mai University

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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85077016490&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/67595

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