The in vitro functional impairment of thyroid hormone receptor alpha 1 isoform mutants is mainly dictated by reduced ligand sensitivity

• Main Authors: Karn Wejaphikul, Anja L.M. van Gucht, Stefan Groeneweg, W. Edward Visser, Theo J. Visser, Robin P. Peeters, Marcel E. Meima
• Format: Journal
• Published: 2020
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85077016490&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/67595
• Institution: Chiang Mai University

© Mary Ann Liebert, Inc. Background: Thyroid hormone (TH) acts on TH receptors (TRs) and regulates gene transcription by binding of TRs to TH response elements (TREs) in target gene promoters. The transcriptional activity of TRs is modulated by interactions with TR-coregulatory proteins. Mutations i...