Protocatechuic acid inhibits inflammatory responses in LPS-activated BV2 microglia via regulating SIRT1/NF-κB pathway contributed to the suppression of microglial activation-induced PC12 cell apoptosis

Protocatechuic acid inhibits inflammatory responses in LPS-activated BV2 microglia via regulating SIRT1/NF-κB pathway contributed to the suppression of microglial activation-induced PC12 cell apoptosis

© 2020 Elsevier B.V. SIRT1 exhibits inhibitory effects on microglial activation-induced neurodegeneration. Regulating SIRT1 may become a novel approach for curing neurodegenerative diseases. Protocatechuic acid (PA), a phenolic acid, has anti-neuroinflammatory effects. The effect of PA on SIRT1 in a...

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Main Authors: Chayanut Kaewmool, Prachya Kongtawelert, Thanyaluck Phitak, Peraphan Pothacharoen, Sasimol Udomruk
Format: Journal
Published: 2020
Subjects:
Immunology and Microbiology
Medicine
Neuroscience
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85078519526&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/68422
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Institution: Chiang Mai University
id th-cmuir.6653943832-68422
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spelling th-cmuir.6653943832-684222020-04-02T15:29:22Z Protocatechuic acid inhibits inflammatory responses in LPS-activated BV2 microglia via regulating SIRT1/NF-κB pathway contributed to the suppression of microglial activation-induced PC12 cell apoptosis Chayanut Kaewmool Prachya Kongtawelert Thanyaluck Phitak Peraphan Pothacharoen Sasimol Udomruk Immunology and Microbiology Medicine Neuroscience © 2020 Elsevier B.V. SIRT1 exhibits inhibitory effects on microglial activation-induced neurodegeneration. Regulating SIRT1 may become a novel approach for curing neurodegenerative diseases. Protocatechuic acid (PA), a phenolic acid, has anti-neuroinflammatory effects. The effect of PA on SIRT1 in activated microglia remains unknown. Here, we examined whether PA has anti-inflammatory effects against microglial activation-induced neuronal cell death via regulating SIRT1 in microglia. We found that PA inhibited the release of inflammatory mediators in LPS-activated BV2 microglia via the SIRT1/NF-κB pathway and thereby attenuated microglial activation-induced PC12 cell apoptosis. This suggests that SIRT1 mediates the anti-neuroinflammatory effects of PA to ameliorate microglial activation-induced neuron death. 2020-04-02T15:26:52Z 2020-04-02T15:26:52Z 2020-04-15 Journal 18728421 01655728 2-s2.0-85078519526 10.1016/j.jneuroim.2020.577164 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85078519526&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/68422
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Immunology and Microbiology
Medicine
Neuroscience
spellingShingle Immunology and Microbiology
Medicine
Neuroscience
Chayanut Kaewmool
Prachya Kongtawelert
Thanyaluck Phitak
Peraphan Pothacharoen
Sasimol Udomruk
Protocatechuic acid inhibits inflammatory responses in LPS-activated BV2 microglia via regulating SIRT1/NF-κB pathway contributed to the suppression of microglial activation-induced PC12 cell apoptosis
description © 2020 Elsevier B.V. SIRT1 exhibits inhibitory effects on microglial activation-induced neurodegeneration. Regulating SIRT1 may become a novel approach for curing neurodegenerative diseases. Protocatechuic acid (PA), a phenolic acid, has anti-neuroinflammatory effects. The effect of PA on SIRT1 in activated microglia remains unknown. Here, we examined whether PA has anti-inflammatory effects against microglial activation-induced neuronal cell death via regulating SIRT1 in microglia. We found that PA inhibited the release of inflammatory mediators in LPS-activated BV2 microglia via the SIRT1/NF-κB pathway and thereby attenuated microglial activation-induced PC12 cell apoptosis. This suggests that SIRT1 mediates the anti-neuroinflammatory effects of PA to ameliorate microglial activation-induced neuron death.
format Journal
author Chayanut Kaewmool
Prachya Kongtawelert
Thanyaluck Phitak
Peraphan Pothacharoen
Sasimol Udomruk
author_facet Chayanut Kaewmool
Prachya Kongtawelert
Thanyaluck Phitak
Peraphan Pothacharoen
Sasimol Udomruk
author_sort Chayanut Kaewmool
title Protocatechuic acid inhibits inflammatory responses in LPS-activated BV2 microglia via regulating SIRT1/NF-κB pathway contributed to the suppression of microglial activation-induced PC12 cell apoptosis
title_short Protocatechuic acid inhibits inflammatory responses in LPS-activated BV2 microglia via regulating SIRT1/NF-κB pathway contributed to the suppression of microglial activation-induced PC12 cell apoptosis
title_full Protocatechuic acid inhibits inflammatory responses in LPS-activated BV2 microglia via regulating SIRT1/NF-κB pathway contributed to the suppression of microglial activation-induced PC12 cell apoptosis
title_fullStr Protocatechuic acid inhibits inflammatory responses in LPS-activated BV2 microglia via regulating SIRT1/NF-κB pathway contributed to the suppression of microglial activation-induced PC12 cell apoptosis
title_full_unstemmed Protocatechuic acid inhibits inflammatory responses in LPS-activated BV2 microglia via regulating SIRT1/NF-κB pathway contributed to the suppression of microglial activation-induced PC12 cell apoptosis
title_sort protocatechuic acid inhibits inflammatory responses in lps-activated bv2 microglia via regulating sirt1/nf-κb pathway contributed to the suppression of microglial activation-induced pc12 cell apoptosis
publishDate 2020
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85078519526&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/68422
_version_ 1681426817143013376

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