EMMPRIN reduction via scFv-M6-1B9 intrabody affects α3β1-integrin and MCT1 functions and results in suppression of progressive phenotype in the colorectal cancer cell line Caco-2

• Main Authors: Sangboonruang S., Thammasit P., Intasai N., Kasinrerk W., Tayapiwatana C., Tragoolpua K.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-84902024588&partnerID=40&md5=5393be25baf2d0a11e11aafe253e0f03; http://cmuir.cmu.ac.th/handle/6653943832/701
• Institution: Chiang Mai University

Extracellular matrix metalloproteinase inducer (EMMPRIN) exhibits overexpression in various cancers and promotes cancer progression and metastasis via the interaction with its associated molecules. The scFv-M6-1B9 intrabody has a potential ability to reduce EMMPRIN cell surface expression. However,...