Prediction of Maternal and Fetal Pharmacokinetics of Dolutegravir and Raltegravir Using Physiologically Based Pharmacokinetic Modeling

Prediction of Maternal and Fetal Pharmacokinetics of Dolutegravir and Raltegravir Using Physiologically Based Pharmacokinetic Modeling

© 2020, Springer Nature Switzerland AG. Background: Predicting drug pharmacokinetics in pregnant women including placental drug transfer remains challenging. This study aimed to develop and evaluate maternal–fetal physiologically based pharmacokinetic models for two antiretroviral drugs, dolutegravi...

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Main Authors: Xiaomei I. Liu, Jeremiah D. Momper, Natella Y. Rakhmanina, Dionna J. Green, Gilbert J. Burckart, Tim R. Cressey, Mark Mirochnick, Brookie M. Best, John N. van den Anker, André Dallmann
格式: 雜誌
出版: 2020
主題:
Medicine
Pharmacology, Toxicology and Pharmaceutics
在線閱讀:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85085392565&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/70978
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機構: Chiang Mai University
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總結:© 2020, Springer Nature Switzerland AG. Background: Predicting drug pharmacokinetics in pregnant women including placental drug transfer remains challenging. This study aimed to develop and evaluate maternal–fetal physiologically based pharmacokinetic models for two antiretroviral drugs, dolutegravir and raltegravir.

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