Prediction of Maternal and Fetal Pharmacokinetics of Dolutegravir and Raltegravir Using Physiologically Based Pharmacokinetic Modeling

© 2020, Springer Nature Switzerland AG. Background: Predicting drug pharmacokinetics in pregnant women including placental drug transfer remains challenging. This study aimed to develop and evaluate maternal–fetal physiologically based pharmacokinetic models for two antiretroviral drugs, dolutegravi...

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Main Authors:	Xiaomei I. Liu, Jeremiah D. Momper, Natella Y. Rakhmanina, Dionna J. Green, Gilbert J. Burckart, Tim R. Cressey, Mark Mirochnick, Brookie M. Best, John N. van den Anker, André Dallmann
Format:	Journal
Published:	2020
Subjects:	Medicine Pharmacology, Toxicology and Pharmaceutics
Online Access:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85085392565&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/70978
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Institution:	Chiang Mai University

id	th-cmuir.6653943832-70978
record_format	dspace
spelling	th-cmuir.6653943832-709782020-10-14T08:48:23Z Prediction of Maternal and Fetal Pharmacokinetics of Dolutegravir and Raltegravir Using Physiologically Based Pharmacokinetic Modeling Xiaomei I. Liu Jeremiah D. Momper Natella Y. Rakhmanina Dionna J. Green Gilbert J. Burckart Tim R. Cressey Mark Mirochnick Brookie M. Best John N. van den Anker André Dallmann Medicine Pharmacology, Toxicology and Pharmaceutics © 2020, Springer Nature Switzerland AG. Background: Predicting drug pharmacokinetics in pregnant women including placental drug transfer remains challenging. This study aimed to develop and evaluate maternal–fetal physiologically based pharmacokinetic models for two antiretroviral drugs, dolutegravir and raltegravir. 2020-10-14T08:45:58Z 2020-10-14T08:45:58Z 2020-01-01 Journal 11791926 03125963 2-s2.0-85085392565 10.1007/s40262-020-00897-9 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85085392565&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/70978
institution	Chiang Mai University
building	Chiang Mai University Library
continent	Asia
country	Thailand Thailand
content_provider	Chiang Mai University Library
collection	CMU Intellectual Repository
topic	Medicine Pharmacology, Toxicology and Pharmaceutics
spellingShingle	Medicine Pharmacology, Toxicology and Pharmaceutics Xiaomei I. Liu Jeremiah D. Momper Natella Y. Rakhmanina Dionna J. Green Gilbert J. Burckart Tim R. Cressey Mark Mirochnick Brookie M. Best John N. van den Anker André Dallmann Prediction of Maternal and Fetal Pharmacokinetics of Dolutegravir and Raltegravir Using Physiologically Based Pharmacokinetic Modeling
description	© 2020, Springer Nature Switzerland AG. Background: Predicting drug pharmacokinetics in pregnant women including placental drug transfer remains challenging. This study aimed to develop and evaluate maternal–fetal physiologically based pharmacokinetic models for two antiretroviral drugs, dolutegravir and raltegravir.
format	Journal
author	Xiaomei I. Liu Jeremiah D. Momper Natella Y. Rakhmanina Dionna J. Green Gilbert J. Burckart Tim R. Cressey Mark Mirochnick Brookie M. Best John N. van den Anker André Dallmann
author_facet	Xiaomei I. Liu Jeremiah D. Momper Natella Y. Rakhmanina Dionna J. Green Gilbert J. Burckart Tim R. Cressey Mark Mirochnick Brookie M. Best John N. van den Anker André Dallmann
author_sort	Xiaomei I. Liu
title	Prediction of Maternal and Fetal Pharmacokinetics of Dolutegravir and Raltegravir Using Physiologically Based Pharmacokinetic Modeling
title_short	Prediction of Maternal and Fetal Pharmacokinetics of Dolutegravir and Raltegravir Using Physiologically Based Pharmacokinetic Modeling
title_full	Prediction of Maternal and Fetal Pharmacokinetics of Dolutegravir and Raltegravir Using Physiologically Based Pharmacokinetic Modeling
title_fullStr	Prediction of Maternal and Fetal Pharmacokinetics of Dolutegravir and Raltegravir Using Physiologically Based Pharmacokinetic Modeling
title_full_unstemmed	Prediction of Maternal and Fetal Pharmacokinetics of Dolutegravir and Raltegravir Using Physiologically Based Pharmacokinetic Modeling
title_sort	prediction of maternal and fetal pharmacokinetics of dolutegravir and raltegravir using physiologically based pharmacokinetic modeling
publishDate	2020
url	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85085392565&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/70978
_version_	1681753001118662656

Prediction of Maternal and Fetal Pharmacokinetics of Dolutegravir and Raltegravir Using Physiologically Based Pharmacokinetic Modeling

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