N,N,N-Trimethyl chitosan nanoparticles for the delivery of monoclonal antibodies against hepatocellular carcinoma cells

• Main Authors: Vongchan P., Wutti-In Y., Sajomsang W., Gonil P., Kothan S., Linhardt R.J.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-79953672031&partnerID=40&md5=d0bc3ce8d307fe8d0b581c4cd6bed471; http://www.ncbi.nlm.nih.gov/pubmed/21552341; http://cmuir.cmu.ac.th/handle/6653943832/757
• Institution: Chiang Mai University

N,N,N-Trimethyl chitosan chloride is capable of forming nanocomplexes with protein through ionotropic gelation. A monoclonal antibody, raised against human liver heparan sulfate proteoglycan and specifically inhibiting hepatocellular carcinoma in vitro, was prepared in nanocomplexes of this modified...