Zinc Finger Protein Designed to Target 2-LTR Junctions Interferes with HIV Integration

• Main Authors: Tayapiwatana C., Sakkhachornphop S., Barbas Iii CF., Keawvichit R., Wongworapat K.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.ncbi.nlm.nih.gov/pubmed/3502482; http://cmuir.cmu.ac.th/handle/6653943832/799
• Institution: Chiang Mai University

Integration of the human immunodeficiency virus type 1 (HIV-1) genome into the host chromosome is a vital step in the HIV life cycle. The highly conserved cytosine-adenine (CA) dinucleotide sequence immediately upstream of the cleavage site is crucial for integrase (IN) activity. As this viral enzym...