Zinc finger protein designed to target 2-long terminal repeat junctions interferes with human immunodeficiency virus integration

Integration of the human immunodeficiency virus type 1 (HIV-1) genome into the host chromosome is a vital step in the HIV life cycle. The highly conserved cytosine-adenine (CA) dinucleotide sequence immediately upstream of the cleavage site is crucial for integrase (IN) activity. As this viral enzym...

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Bibliographic Details
Main Authors: Sakkhachornphop S., Barbas C.F., Keawvichit R., Wongworapat K., Tayapiwatana C.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-84866325679&partnerID=40&md5=8566b0689be01855e3a4fb2b8a76e98c
http://cmuir.cmu.ac.th/handle/6653943832/909
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Institution: Chiang Mai University
Language: English