Zinc finger protein designed to target 2-long terminal repeat junctions interferes with human immunodeficiency virus integration

• Main Authors: Sakkhachornphop S., Barbas C.F., Keawvichit R., Wongworapat K., Tayapiwatana C.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-84866325679&partnerID=40&md5=8566b0689be01855e3a4fb2b8a76e98c; http://cmuir.cmu.ac.th/handle/6653943832/909
• Institution: Chiang Mai University

Integration of the human immunodeficiency virus type 1 (HIV-1) genome into the host chromosome is a vital step in the HIV life cycle. The highly conserved cytosine-adenine (CA) dinucleotide sequence immediately upstream of the cleavage site is crucial for integrase (IN) activity. As this viral enzym...