Emetine regulates the alternative splicing of caspase 9 in tumor cells

• Main Authors: Danmin Pan, Kritsanapol Boon-Unge, Piyarat Govitrapong, Jianhua Zhou
• Other Authors: Nantong University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/11444
• Institution: Mahidol University

Exons 3 to 6 in the caspase 9 gene undergo alternative splicing in which the larger caspase 9 splice variant promotes apoptosis, in contrast to the dominant negative anti-apoptotic splice variant, the smaller caspase 9b. In this study, the regulation of the alternative splicing of caspase 9 pre-mRNA...