Binding of flavivirus nonstructural protein NS1 to C4b binding protein modulates complement activation

• Main Authors: Panisadee Avirutnan, Richard E. Hauhart, Pawit Somnuke, Anna M. Blom, Michael S. Diamond, John P. Atkinson
• Other Authors: Washington University in St. Louis, School of Medicine
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/12028
• Institution: Mahidol University

The complement system plays a pivotal protective role in the innate immune response to many pathogens including flaviviruses. Flavivirus nonstructural protein 1 (NS1) is a secreted nonstructural glycoprotein that accumulates in plasma to high levels and is displayed on the surface of infected cells...