Enhancing Blockade of Plasmodium falciparum Erythrocyte Invasion: Assessing Combinations of Antibodies against PfRH5 and Other Merozoite Antigens

• Main Authors: Andrew R. Williams, Alexander D. Douglas, Kazutoyo Miura, Joseph J. Illingworth, Prateek Choudhary, Linda M. Murungi, Julie M. Furze, Ababacar Diouf, Olivo Miotto, Cécile Crosnier, Gavin J. Wright, Dominic P. Kwiatkowski, Rick M. Fairhurst, Carole A. Long, Simon J. Draper
• Other Authors: University of Oxford
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/13584
• Institution: Mahidol University

No vaccine has yet proven effective against the blood-stages of Plasmodium falciparum, which cause the symptoms and severe manifestations of malaria. We recently found that PfRH5, a P. falciparum-specific protein expressed in merozoites, is efficiently targeted by broadly-neutralizing, vaccine-induc...