Evidence that the erythrocyte invasion ligand PfRh2 is a target of protective immunity against Plasmodium falciparum malaria

• Main Authors: Linda Reiling, Jack S. Richards, Freya J.I. Fowkes, Alyssa E. Barry, Tony Triglia, Watcharee Chokejindachai, Pascal Michon, Livingstone Tavul, Peter M. Siba, Alan F. Cowman, Ivo Mueller, James G. Beeson
• Other Authors: Walter and Eliza Hall Institute of Medical Research
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/29177
• Institution: Mahidol University

Abs targeting blood-stage Ags of Plasmodium falciparum are important in acquired immunity to malaria, but major targets remain unclear. The P. falciparum reticulocyte-binding homologs (PfRh) are key ligands used by merozoites during invasion of erythrocytes. PfRh2a and PfRh2b are functionally import...