Allosteric regulation of the biotin-dependent enzyme pyruvate carboxylase by acetyl-CoA

• Main Authors: Abdussalam Adina-Zada, Tonya N. Zeczycki, Martin St Maurice, Sarawut Jitrapakdee, W. Wallace Cleland, Paul V. Attwood
• Other Authors: University of Western Australia
• Format: Conference or Workshop Item
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/13716
• Institution: Mahidol University

The activity of the biotin-dependent enzyme pyruvate carboxylase from many organisms is highly regulated by the allosteric activator acetyl-CoA. A number of X-ray crystallographic structures of the native pyruvate carboxylase tetramer are now available for the enzyme from Rhizobium etli and Staphylo...