Cationic liposomes extend the immunostimulatory effect of CpG oligodeoxynucleotide against burkholderia pseudomallei infection in BALB/c mice

• Main Authors: Apichaya Puangpetch, Robert Anderson, Yan Y. Huang, Rasana W. Sermswan, Wanpen Chaicumpa, Stitaya Sirisinha, Surasakdi Wongratanacheewina
• Other Authors: Khon Kaen University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/13746
• Institution: Mahidol University

Melioidosis is a severe disease caused by the Gram-negative bacterium Burkholderia pseudomallei. Previously we showed that pretreatment of mice with CpG oligodeoxynucleotide (CpG ODN) 2 to 10 days prior to B. pseudomallei challenge conferred as high as 90% protection, but this window of protection w...