T-type calcium channel blockade improves survival and cardiovascular function in thalassemic mice

• Main Authors: Sirinart Kumfu, Siriporn Chattipakorn, Kroekkiat Chinda, Suthat Fucharoen, Nipon Chattipakorn
• Other Authors: Faculty of Medicine, Chiang Mai University
• Format: Article
• Published: 2018
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/14788
• Institution: Mahidol University

Objectives: Iron-overload cardiomyopathy is a major cause of morbidity and mortality in patients with thalassemia. However, the precise mechanisms of iron entry and sequestration in the heart are still unclear. Our previous study showed that Fe 2+ uptake in thalassemic cardiomyocytes are mainly me...