Population pharmacokinetics and pharmacodynamics of piperaquine in children with uncomplicated falciparum malaria

• Main Authors: J. Tarning, I. Zongo, F. A. Somé, N. Rouamba, S. Parikh, P. J. Rosenthal, W. Hanpithakpong, N. Jongrak, N. P.J. Day, N. J. White, F. Nosten, J. B. Ouedraogo, N. Lindegardh
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/14942

Dihydroartemisinin-piperaquine is being increasingly used as a first-line artemisinin combination treatment for malaria. The aim of this study was to describe the pharmacokinetic and pharmacodynamic properties of piperaquine in 236 children with uncomplicated falciparum malaria in Burkina Faso. They...