Population pharmacokinetics and pharmacodynamics of piperaquine in children with uncomplicated falciparum malaria
Dihydroartemisinin-piperaquine is being increasingly used as a first-line artemisinin combination treatment for malaria. The aim of this study was to describe the pharmacokinetic and pharmacodynamic properties of piperaquine in 236 children with uncomplicated falciparum malaria in Burkina Faso. They...
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th-mahidol.149422018-06-11T12:24:08Z Population pharmacokinetics and pharmacodynamics of piperaquine in children with uncomplicated falciparum malaria J. Tarning I. Zongo F. A. Somé N. Rouamba S. Parikh P. J. Rosenthal W. Hanpithakpong N. Jongrak N. P.J. Day N. J. White F. Nosten J. B. Ouedraogo N. Lindegardh Mahidol University Nuffield Department of Clinical Medicine Institut de Recherche en Sciences de la Santé University of California, San Francisco Shoklo Malaria Research Unit Medicine Pharmacology, Toxicology and Pharmaceutics Dihydroartemisinin-piperaquine is being increasingly used as a first-line artemisinin combination treatment for malaria. The aim of this study was to describe the pharmacokinetic and pharmacodynamic properties of piperaquine in 236 children with uncomplicated falciparum malaria in Burkina Faso. They received a standard body weight-based oral 3-day fixed-dose dihydroartemisinin- piperaquine regimen. Capillary plasma concentration-time profiles were characterized using nonlinear mixed-effects modeling. The population pharmacokinetics of piperaquine were described accurately by a two-transit-compartment absorption model and a three-compartment distribution model. Body weight was a significant covariate affecting clearance and volume parameters. The individually predicted day 7 capillary plasma concentration of piperaquine was an important predictor (P < 0.0001) of recurrent malaria infection after treatment. Young children (2-5 years of age) received a significantly higher body weight-normalized dose than older children (P = 0.025) but had significantly lower day 7 piperaquine concentrations (P = 0.024) and total piperaquine exposures (P = 0.021), suggesting that an increased dose regimen for young children should be evaluated. © 2012 american Society for clinical Pharmacology and Therapeutics. 2018-06-11T05:15:35Z 2018-06-11T05:15:35Z 2012-03-01 Article Clinical Pharmacology and Therapeutics. Vol.91, No.3 (2012), 497-505 10.1038/clpt.2011.254 15326535 00099236 2-s2.0-84857233900 https://repository.li.mahidol.ac.th/handle/123456789/14942 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84857233900&origin=inward |
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Medicine Pharmacology, Toxicology and Pharmaceutics J. Tarning I. Zongo F. A. Somé N. Rouamba S. Parikh P. J. Rosenthal W. Hanpithakpong N. Jongrak N. P.J. Day N. J. White F. Nosten J. B. Ouedraogo N. Lindegardh Population pharmacokinetics and pharmacodynamics of piperaquine in children with uncomplicated falciparum malaria |
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Dihydroartemisinin-piperaquine is being increasingly used as a first-line artemisinin combination treatment for malaria. The aim of this study was to describe the pharmacokinetic and pharmacodynamic properties of piperaquine in 236 children with uncomplicated falciparum malaria in Burkina Faso. They received a standard body weight-based oral 3-day fixed-dose dihydroartemisinin- piperaquine regimen. Capillary plasma concentration-time profiles were characterized using nonlinear mixed-effects modeling. The population pharmacokinetics of piperaquine were described accurately by a two-transit-compartment absorption model and a three-compartment distribution model. Body weight was a significant covariate affecting clearance and volume parameters. The individually predicted day 7 capillary plasma concentration of piperaquine was an important predictor (P < 0.0001) of recurrent malaria infection after treatment. Young children (2-5 years of age) received a significantly higher body weight-normalized dose than older children (P = 0.025) but had significantly lower day 7 piperaquine concentrations (P = 0.024) and total piperaquine exposures (P = 0.021), suggesting that an increased dose regimen for young children should be evaluated. © 2012 american Society for clinical Pharmacology and Therapeutics. |
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Mahidol University |
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Mahidol University J. Tarning I. Zongo F. A. Somé N. Rouamba S. Parikh P. J. Rosenthal W. Hanpithakpong N. Jongrak N. P.J. Day N. J. White F. Nosten J. B. Ouedraogo N. Lindegardh |
format |
Article |
author |
J. Tarning I. Zongo F. A. Somé N. Rouamba S. Parikh P. J. Rosenthal W. Hanpithakpong N. Jongrak N. P.J. Day N. J. White F. Nosten J. B. Ouedraogo N. Lindegardh |
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J. Tarning |
title |
Population pharmacokinetics and pharmacodynamics of piperaquine in children with uncomplicated falciparum malaria |
title_short |
Population pharmacokinetics and pharmacodynamics of piperaquine in children with uncomplicated falciparum malaria |
title_full |
Population pharmacokinetics and pharmacodynamics of piperaquine in children with uncomplicated falciparum malaria |
title_fullStr |
Population pharmacokinetics and pharmacodynamics of piperaquine in children with uncomplicated falciparum malaria |
title_full_unstemmed |
Population pharmacokinetics and pharmacodynamics of piperaquine in children with uncomplicated falciparum malaria |
title_sort |
population pharmacokinetics and pharmacodynamics of piperaquine in children with uncomplicated falciparum malaria |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/14942 |
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1763494578206277632 |