Effect of grinding of β-cyclodextrin and glibenclamide on tablet properties. Part I. In vitro
Physical properties including dissolution characteristics of glibenclamide (GB) tablets were studied. Directly compressed and wet-granulated GB tablets gave only 35% and 40% drug dissolved, respectively. Physical mixing, kneading, and grinding of β-cyclodextrin (CD) with CB were investigated. It was...
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th-mahidol.175822018-07-04T14:34:31Z Effect of grinding of β-cyclodextrin and glibenclamide on tablet properties. Part I. In vitro Ampol Mitrevej Nuttanan Sinchaipanid Varaporn Junyaprasert Ladda Warintornuwat Mahidol University Chemistry Pharmacology, Toxicology and Pharmaceutics Physical properties including dissolution characteristics of glibenclamide (GB) tablets were studied. Directly compressed and wet-granulated GB tablets gave only 35% and 40% drug dissolved, respectively. Physical mixing, kneading, and grinding of β-cyclodextrin (CD) with CB were investigated. It was found that the grinding method could markedly enhance the release of drug from the tablets. The physical properties of these tablets were unchanged after they had been stored at 40°C and 75% RH for at least 3 months. The GB/CD mixture at a ratio of 1 to 4, ground for 24 or 48 hr, exhibited superior dissolution and chemical stability. Differential scanning calorimetry indicated that an inclusion complex was produced. Decreasing grinding time or CD concentration could result in incomplete formation of the inclusion complex. It was concluded that pretreatment of the drug with CD by the grinding method could significantly improve the dissolution and stability of GB tablets. 2018-07-04T07:23:29Z 2018-07-04T07:23:29Z 1996-01-01 Article Drug Development and Industrial Pharmacy. Vol.22, No.12 (1996), 1237-1241 10.3109/03639049609063243 03639045 2-s2.0-0029802558 https://repository.li.mahidol.ac.th/handle/123456789/17582 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0029802558&origin=inward |
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Chemistry Pharmacology, Toxicology and Pharmaceutics Ampol Mitrevej Nuttanan Sinchaipanid Varaporn Junyaprasert Ladda Warintornuwat Effect of grinding of β-cyclodextrin and glibenclamide on tablet properties. Part I. In vitro |
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Physical properties including dissolution characteristics of glibenclamide (GB) tablets were studied. Directly compressed and wet-granulated GB tablets gave only 35% and 40% drug dissolved, respectively. Physical mixing, kneading, and grinding of β-cyclodextrin (CD) with CB were investigated. It was found that the grinding method could markedly enhance the release of drug from the tablets. The physical properties of these tablets were unchanged after they had been stored at 40°C and 75% RH for at least 3 months. The GB/CD mixture at a ratio of 1 to 4, ground for 24 or 48 hr, exhibited superior dissolution and chemical stability. Differential scanning calorimetry indicated that an inclusion complex was produced. Decreasing grinding time or CD concentration could result in incomplete formation of the inclusion complex. It was concluded that pretreatment of the drug with CD by the grinding method could significantly improve the dissolution and stability of GB tablets. |
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Mahidol University |
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Mahidol University Ampol Mitrevej Nuttanan Sinchaipanid Varaporn Junyaprasert Ladda Warintornuwat |
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Ampol Mitrevej Nuttanan Sinchaipanid Varaporn Junyaprasert Ladda Warintornuwat |
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Ampol Mitrevej |
title |
Effect of grinding of β-cyclodextrin and glibenclamide on tablet properties. Part I. In vitro |
title_short |
Effect of grinding of β-cyclodextrin and glibenclamide on tablet properties. Part I. In vitro |
title_full |
Effect of grinding of β-cyclodextrin and glibenclamide on tablet properties. Part I. In vitro |
title_fullStr |
Effect of grinding of β-cyclodextrin and glibenclamide on tablet properties. Part I. In vitro |
title_full_unstemmed |
Effect of grinding of β-cyclodextrin and glibenclamide on tablet properties. Part I. In vitro |
title_sort |
effect of grinding of β-cyclodextrin and glibenclamide on tablet properties. part i. in vitro |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/17582 |
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1763494728049885184 |