Platelet inhibition by nitrite is dependent on erythrocytes and deoxygenation

• Main Authors: Sirada Srihirun, Thanaporn Sriwantana, Supeenun Unchern, Dusadee Kittikool, Egarit Noulsri, Kovit Pattanapanyasat, Suthat Fucharoen, Barbora Piknova, Alan N. Schechter, Nathawut Sibmooh
• Other Authors: Mahidol University. Institute of Science and Technology for Research and Development. Thalassemia Research Center
• Format: Article
• Language: English
• Published: 2015
• Subjects: Antioxidant activity; Crocodylus siamensis; Hemoglobin; Secondary structure; Open Access article
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/1800
• Institution: Mahidol University

Background Nitrite is a nitric oxide (NO) metabolite in tissues and blood, which can be converted to NO under hypoxia to facilitate tissue perfusion. Although nitrite is known to cause vasodilation following its reduction to NO, the effect of nitrite on platelet activity remains unclear. In this st...