Oxidation of iron-nitrosyl-hemoglobin by dehydroascorbic acid releases nitric oxide to form nitrite in human erythrocytes

• Main Authors: Nathawut Sibmooh, Barbora Piknova, Fabiola Rizzatti, Alan N. Schechter
• Other Authors: National Institute of Diabetes and Digestive and Kidney Diseases
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/18952
• Institution: Mahidol University

The reaction of deoxyhemoglobin with nitric oxide (NO) or nitrite ions (NO2-) produces ironnitrosyl-hemoglobin (HbNO) in contrast to the reaction with oxyhemoglobin, which produces methemoglobin and nitrate (NO3-). HbNO has not been associated with the known bioactivities of NO. We hypothesized that...