Structure, mechanism and regulation of pyruvate carboxylase

PC (pyruvate carboxylase) is a biotin-containing enzyme that catalyses the HCO3-- and MgATP-dependent carboxylation of pyruvate to form oxaloacetate. This is a very important anaplerotic reaction, replenishing oxaloacetate withdrawn from the tricarboxylic acid cycle for various pivotal biochemical p...

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Bibliographic Details
Main Authors: Sarawut Jitrapakdee, Martin St Maurice, Ivan Rayment, W. Wallace Cleland, John C. Wallace, Paul V. Attwood
Other Authors: Mahidol University
Format: Review
Published: 2018
Subjects:
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/18883
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Institution: Mahidol University