Effect of five-membered sugar mimics on mammalian glycogen-degrading enzymes and various glucosidases

• Main Authors: Yasuhiro Minami, Chinami Kuriyama, Kyoko Ikeda, Atsushi Kato, Kenji Takebayashi, Isao Adachi, George W J Fleet, Aikkarach Kettawan, Tadashi Okamoto, Naoki Asano
• Other Authors: Hokuriku University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/18951
• Institution: Mahidol University

We investigated inhibitory activities of five-membered sugar mimics toward glycogen-degrading enzymes and a variety of glucosidases. 1,4-Dideoxy-1,4-imino-d-arabinitol (d-AB1) is known to be a potent inhibitor of glycogen phosphorylase. However, the structural modification of d-AB1, such as its enan...