The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria
Background. Malaria is a very important cause of anaemia in tropical countries. Anaemia is assessed either by measurement of the haematocrit or the haemoglobin concentration. For comparisons across studies, it is often necessary to derive one measure from the other. Methods. Data on patients with sl...
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th-mahidol.193012018-07-12T09:39:38Z The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria Sue J. Lee Kasia Stepniewska Nicholas Anstey Elizabeth Ashley Karen Barnes Tran Quang Binh Umberto D'Alessandro Nicholas P.J. Day Peter J. De Vries Grant Dorsey Jean Paul Guthmann Mayfong Mayxay Paul Newton Francois Nosten Piero Olliaro Lyda Osario Loretxu Pinoges Ric Price Mark Rowland Frank Smithuis Robert Taylor Nicholas J. White Mahidol University Royal Darwin Hospital Shoklo Malaria Research Unit University of Cape Town Choray Hospital Prins Leopold Instituut voor Tropische Geneeskunde Centre for Clinical Vaccinology and Tropical Medicine Academic Medical Centre, University of Amsterdam University of California, San Francisco Institut de Recherche en Sciences de la Santé Uganda Malaria Surveillance Program Epicentre National University of Laos University of Oxford Organisation Mondiale de la Sante Centro Internatcional de Entrenamiento e Investigaciones Medicas London School of Hygiene & Tropical Medicine Immunology and Microbiology Medicine Background. Malaria is a very important cause of anaemia in tropical countries. Anaemia is assessed either by measurement of the haematocrit or the haemoglobin concentration. For comparisons across studies, it is often necessary to derive one measure from the other. Methods. Data on patients with slide-confirmed uncomplicated falciparum malaria were pooled from 85 antimalarial drug trials conducted in 25 different countries, to assess the haemoglobin/haematocrit relationship at different time points in malaria. Using a linear random effects model, a conversion equation for haematocrit was derived based on 3,254 measurements from various time points (ranging from day 0 to day 63) from 1,810 patients with simultaneous measurements of both parameters. Haemoglobin was also estimated from haematocrit with the commonly used threefold conversion. Results. A good fit was obtained using Haematocrit = 5.62 + 2.60 * Haemoglobin. On average, haematocrit/3 levels were slightly higher than haemoglobin measurements with a mean difference (± SD) of -0.69 (± 1.3) for children under the age of 5 (n = 1,440 measurements from 449 patients). Conclusion. Based on this large data set, an accurate and robust conversion factor both in acute malaria and in convalescence was obtained. The commonly used threefold conversion is also valid. © 2008 Lee et al; licensee BioMed Central Ltd. 2018-07-12T02:29:35Z 2018-07-12T02:29:35Z 2008-08-22 Article Malaria Journal. Vol.7, (2008) 10.1186/1475-2875-7-149 14752875 2-s2.0-49649123369 https://repository.li.mahidol.ac.th/handle/123456789/19301 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=49649123369&origin=inward |
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Immunology and Microbiology Medicine Sue J. Lee Kasia Stepniewska Nicholas Anstey Elizabeth Ashley Karen Barnes Tran Quang Binh Umberto D'Alessandro Nicholas P.J. Day Peter J. De Vries Grant Dorsey Jean Paul Guthmann Mayfong Mayxay Paul Newton Francois Nosten Piero Olliaro Lyda Osario Loretxu Pinoges Ric Price Mark Rowland Frank Smithuis Robert Taylor Nicholas J. White The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria |
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Background. Malaria is a very important cause of anaemia in tropical countries. Anaemia is assessed either by measurement of the haematocrit or the haemoglobin concentration. For comparisons across studies, it is often necessary to derive one measure from the other. Methods. Data on patients with slide-confirmed uncomplicated falciparum malaria were pooled from 85 antimalarial drug trials conducted in 25 different countries, to assess the haemoglobin/haematocrit relationship at different time points in malaria. Using a linear random effects model, a conversion equation for haematocrit was derived based on 3,254 measurements from various time points (ranging from day 0 to day 63) from 1,810 patients with simultaneous measurements of both parameters. Haemoglobin was also estimated from haematocrit with the commonly used threefold conversion. Results. A good fit was obtained using Haematocrit = 5.62 + 2.60 * Haemoglobin. On average, haematocrit/3 levels were slightly higher than haemoglobin measurements with a mean difference (± SD) of -0.69 (± 1.3) for children under the age of 5 (n = 1,440 measurements from 449 patients). Conclusion. Based on this large data set, an accurate and robust conversion factor both in acute malaria and in convalescence was obtained. The commonly used threefold conversion is also valid. © 2008 Lee et al; licensee BioMed Central Ltd. |
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Mahidol University |
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Mahidol University Sue J. Lee Kasia Stepniewska Nicholas Anstey Elizabeth Ashley Karen Barnes Tran Quang Binh Umberto D'Alessandro Nicholas P.J. Day Peter J. De Vries Grant Dorsey Jean Paul Guthmann Mayfong Mayxay Paul Newton Francois Nosten Piero Olliaro Lyda Osario Loretxu Pinoges Ric Price Mark Rowland Frank Smithuis Robert Taylor Nicholas J. White |
format |
Article |
author |
Sue J. Lee Kasia Stepniewska Nicholas Anstey Elizabeth Ashley Karen Barnes Tran Quang Binh Umberto D'Alessandro Nicholas P.J. Day Peter J. De Vries Grant Dorsey Jean Paul Guthmann Mayfong Mayxay Paul Newton Francois Nosten Piero Olliaro Lyda Osario Loretxu Pinoges Ric Price Mark Rowland Frank Smithuis Robert Taylor Nicholas J. White |
author_sort |
Sue J. Lee |
title |
The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria |
title_short |
The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria |
title_full |
The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria |
title_fullStr |
The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria |
title_full_unstemmed |
The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria |
title_sort |
relationship between the haemoglobin concentration and the haematocrit in plasmodium falciparum malaria |
publishDate |
2018 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/19301 |
_version_ |
1763491373922648064 |