The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria

• Main Authors: Sue J. Lee, Kasia Stepniewska, Nicholas Anstey, Elizabeth Ashley, Karen Barnes, Tran Quang Binh, Umberto D'Alessandro, Nicholas P.J. Day, Peter J. De Vries, Grant Dorsey, Jean Paul Guthmann, Mayfong Mayxay, Paul Newton, Francois Nosten, Piero Olliaro, Lyda Osario, Loretxu Pinoges, Ric Price, Mark Rowland, Frank Smithuis, Robert Taylor, Nicholas J. White
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/19301

Background. Malaria is a very important cause of anaemia in tropical countries. Anaemia is assessed either by measurement of the haematocrit or the haemoglobin concentration. For comparisons across studies, it is often necessary to derive one measure from the other. Methods. Data on patients with slide-confirmed uncomplicated falciparum malaria were pooled from 85 antimalarial drug trials conducted in 25 different countries, to assess the haemoglobin/haematocrit relationship at different time points in malaria. Using a linear random effects model, a conversion equation for haematocrit was derived based on 3,254 measurements from various time points (ranging from day 0 to day 63) from 1,810 patients with simultaneous measurements of both parameters. Haemoglobin was also estimated from haematocrit with the commonly used threefold conversion. Results. A good fit was obtained using Haematocrit = 5.62 + 2.60 * Haemoglobin. On average, haematocrit/3 levels were slightly higher than haemoglobin measurements with a mean difference (± SD) of -0.69 (± 1.3) for children under the age of 5 (n = 1,440 measurements from 449 patients). Conclusion. Based on this large data set, an accurate and robust conversion factor both in acute malaria and in convalescence was obtained. The commonly used threefold conversion is also valid. © 2008 Lee et al; licensee BioMed Central Ltd.