Human monoclonal single chain antibodies (HuScFv) that bind to the polymerase proteins of influenza A virus

• Main Authors: Umaporn Thathaisong, Santi Maneewatch, Kasem Kulkeaw, Kanyarat Thueng-In, Ornutcha Poungpair, Potjanee Srimanote, Thaweesak Songserm, Pongsri Tongtawe, Pramuan Tapchaisri, Wanpen Chaicumpa
• Other Authors: Thammasat University
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/19366
• Institution: Mahidol University

Current anti-influenza drugs target the viral neuraminidase or inhibit the function of the ion channel M2 protein. Not only is the supply of these drugs unlikely to meet the demand during a large influenza epidemic/pandemic, but also has an emergence of drug resistant influenza virus variants been d...