Human monoclonal ScFv that bind to different functional domains of M2 and inhibit H5N1 influenza virus replication

• Main Authors: Tippawan Pissawong, Santi Maneewatch, Kanyarat Thueng-in, Potjanee Srimanote, Fonthip Dong-din-on, Jeeraphong Thanongsaksrikul, Thaweesak Songserm, Pongsri Tongtawe, Kunan Bangphoomi, Wanpen Chaicumpa
• Other Authors: Mahidol University. Faculty of Medicine Siriraj Hospital. Laboratory for Research and Technology Development
• Format: Article
• Language: English
• Published: 2017
• Subjects: Influenza virus; H5N1; M2 protein; Human ScFv; Phage display; Virus neutralization; Quantitative real-time RT-PCR; Mimotope; Molecular docking; Open Access article
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/2801
• Institution: Mahidol University

Background: Novel effective anti-influenza agent that tolerates influenza virus antigenic variation is needed. Highly conserved influenza virus M2 protein has multiple pivotal functions including ion channel activity for vRNP uncoating, anti-autophagy and virus assembly, morphogenesis and release....