Human monoclonal ScFv specific to NS1 protein inhibits replication of influenza viruses across types and subtypes

• Main Authors: Rungrueang Yodsheewan, Santi Maneewatch, Potjanee Srimanote, Kanyarat Thueng-In, Thaweesak Songserm, Fonthip Dong-Din-On, Kunan Bangphoomi, Nitat Sookrung, Kiattawee Choowongkomon, Wanpen Chaicumpa
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/31870

Currently, there is a need of new anti-influenza agents that target influenza virus proteins other than ion channel M2 and neuraminidase. Non-structural protein-1 (NS1) is a highly conserved multifunctional protein which is indispensable for the virus replication cycle. In this study, fully human si...