Complexin II plays a positive role in Ca²⁺-triggered exocytosis by facilitating vesicle priming

• Main Authors: Haijiang Cai, Kerstin Reim, Frederique Varoqueaux, Sompol Tapechum, Kerstin Hill, Jakob B. Sørensen, Nils Brose, Robert H. Chow
• Other Authors: University of Southern California
• Format: Article
• Published: 2018
• Subjects: Multidisciplinary
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/19920
• Institution: Mahidol University

SNARE-mediated exocytosis is a multistage process central to synaptic transmission and hormone release. Complexins (CPXs) are small proteins that bind very rapidly and with a high affinity to the SNARE core complex, where they have been proposed recently to inhibit exocytosis by clamping the complex...