Plasmodium berghei: Lactic acidosis and hypoglycaemia in a rodent model of severe malaria; effects of glucose, quinine, and dichloroacetate
Fulminant malaria infections are characterised by hypoglycaemia and potentially lethal lactic acidosis. In young adult Wistar rats (n = 26) infected with Plasmodium berghei (ANKA strain), hyperparasitaemia (>50%), anaemia (PCV 19.6 ± 5.3%; mean ± SD) hypoglycaemia (1.04 ± 0.74 mmol/litre), hyperl...
Saved in:
Main Authors: | Paul A.H. Holloway, Sanjeev Krishna, Nicholas J. White |
---|---|
Other Authors: | John Radcliffe Hospital |
Format: | Article |
Published: |
2018
|
Subjects: | |
Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/22058 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Mahidol University |
Similar Items
-
Plasmodium berghei Infection: Dichloroacetate improves survival in rats with lactic acidosis
by: P. A. Holloway, et al.
Published: (2018) -
Dichloroacetate for lactic acidosis in severe malaria: A pharmacokinetic and pharmacodynamic assessment
by: S. Krishna, et al.
Published: (2018) -
Lactic acidosis and hypoglycaemia in children with severe malaria: Pathophysiological and prognostic significance
by: S. Krishna, et al.
Published: (2018) -
Pharmacokinetics and pharmacodynamics of dichloroacetate in children with lactic acidosis due to severe malaria
by: S. Krishna, et al.
Published: (2018) -
The disposition and effects of two doses of dichloroacetate in adults with severe falciparum malaria
by: Sanjeev Krishna, et al.
Published: (2018)