Plasmodium berghei: Lactic acidosis and hypoglycaemia in a rodent model of severe malaria; effects of glucose, quinine, and dichloroacetate

• Main Authors: Paul A.H. Holloway, Sanjeev Krishna, Nicholas J. White
• Other Authors: John Radcliffe Hospital
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/22058
• Institution: Mahidol University

Fulminant malaria infections are characterised by hypoglycaemia and potentially lethal lactic acidosis. In young adult Wistar rats (n = 26) infected with Plasmodium berghei (ANKA strain), hyperparasitaemia (>50%), anaemia (PCV 19.6 ± 5.3%; mean ± SD) hypoglycaemia (1.04 ± 0.74 mmol/litre), hyperl...