Antimalarial activity of biflavonoids from Ochna integerrima

Antimalarial activity of biflavonoids from Ochna integerrima

During the screening of antimalarial substances, the 80% EtOH extract from the outer bark of Ochna integerrima Merr. (Ochnaceae) was shown to have a good anti-malarial activity (IC50 value: 6.5 μg/mL) whereas extracts from the inner barks of O. integerrima showed no antimalarial activity. Biflavanon...

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Bibliographic Details
Main Authors: Chikara Ichino, Hiroaki Kiyohara, Noppamas Soonthornchareonnon, Wongsatit Chuakul, Aki Ishiyama, Hitomi Sekiguchi, Miyuki Namatame, Kazuhiko Otoguro, Satoshi Omura, Haruki Yamada
Other Authors: Kitasato University
Format: Article
Published: 2018
Subjects:
Agricultural and Biological Sciences
Chemistry
Pharmacology, Toxicology and Pharmaceutics
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/22892
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Institution: Mahidol University
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Summary:During the screening of antimalarial substances, the 80% EtOH extract from the outer bark of Ochna integerrima Merr. (Ochnaceae) was shown to have a good anti-malarial activity (IC50 value: 6.5 μg/mL) whereas extracts from the inner barks of O. integerrima showed no antimalarial activity. Biflavanone (1), which had not been found previously from a natural plant source, was isolated as a potent antimalarial active ingredient (IC50 value: 80 ng/mL) from the extract of the outer barks. The stereoisomer of 1 (= compound 2) was also isolated from this plant; however, its activity was significantly lower than that of 1. © Georg Thieme Verlag KG Stuttgart.

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