Antimalarial activity of biflavonoids from Ochna integerrima
During the screening of antimalarial substances, the 80% EtOH extract from the outer bark of Ochna integerrima Merr. (Ochnaceae) was shown to have a good anti-malarial activity (IC50 value: 6.5 μg/mL) whereas extracts from the inner barks of O. integerrima showed no antimalarial activity. Biflavanon...
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th-mahidol.228922018-08-20T14:24:42Z Antimalarial activity of biflavonoids from Ochna integerrima Chikara Ichino Hiroaki Kiyohara Noppamas Soonthornchareonnon Wongsatit Chuakul Aki Ishiyama Hitomi Sekiguchi Miyuki Namatame Kazuhiko Otoguro Satoshi Omura Haruki Yamada Kitasato University The Kitasato Institute Mahidol University Agricultural and Biological Sciences Chemistry Pharmacology, Toxicology and Pharmaceutics During the screening of antimalarial substances, the 80% EtOH extract from the outer bark of Ochna integerrima Merr. (Ochnaceae) was shown to have a good anti-malarial activity (IC50 value: 6.5 μg/mL) whereas extracts from the inner barks of O. integerrima showed no antimalarial activity. Biflavanone (1), which had not been found previously from a natural plant source, was isolated as a potent antimalarial active ingredient (IC50 value: 80 ng/mL) from the extract of the outer barks. The stereoisomer of 1 (= compound 2) was also isolated from this plant; however, its activity was significantly lower than that of 1. © Georg Thieme Verlag KG Stuttgart. 2018-08-20T06:48:02Z 2018-08-20T06:48:02Z 2006-06-01 Article Planta Medica. Vol.72, No.7 (2006), 611-614 10.1055/s-2006-931569 00320943 2-s2.0-33745726233 https://repository.li.mahidol.ac.th/handle/123456789/22892 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33745726233&origin=inward |
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Agricultural and Biological Sciences Chemistry Pharmacology, Toxicology and Pharmaceutics Chikara Ichino Hiroaki Kiyohara Noppamas Soonthornchareonnon Wongsatit Chuakul Aki Ishiyama Hitomi Sekiguchi Miyuki Namatame Kazuhiko Otoguro Satoshi Omura Haruki Yamada Antimalarial activity of biflavonoids from Ochna integerrima |
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During the screening of antimalarial substances, the 80% EtOH extract from the outer bark of Ochna integerrima Merr. (Ochnaceae) was shown to have a good anti-malarial activity (IC50 value: 6.5 μg/mL) whereas extracts from the inner barks of O. integerrima showed no antimalarial activity. Biflavanone (1), which had not been found previously from a natural plant source, was isolated as a potent antimalarial active ingredient (IC50 value: 80 ng/mL) from the extract of the outer barks. The stereoisomer of 1 (= compound 2) was also isolated from this plant; however, its activity was significantly lower than that of 1. © Georg Thieme Verlag KG Stuttgart. |
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Kitasato University |
author_facet |
Kitasato University Chikara Ichino Hiroaki Kiyohara Noppamas Soonthornchareonnon Wongsatit Chuakul Aki Ishiyama Hitomi Sekiguchi Miyuki Namatame Kazuhiko Otoguro Satoshi Omura Haruki Yamada |
format |
Article |
author |
Chikara Ichino Hiroaki Kiyohara Noppamas Soonthornchareonnon Wongsatit Chuakul Aki Ishiyama Hitomi Sekiguchi Miyuki Namatame Kazuhiko Otoguro Satoshi Omura Haruki Yamada |
author_sort |
Chikara Ichino |
title |
Antimalarial activity of biflavonoids from Ochna integerrima |
title_short |
Antimalarial activity of biflavonoids from Ochna integerrima |
title_full |
Antimalarial activity of biflavonoids from Ochna integerrima |
title_fullStr |
Antimalarial activity of biflavonoids from Ochna integerrima |
title_full_unstemmed |
Antimalarial activity of biflavonoids from Ochna integerrima |
title_sort |
antimalarial activity of biflavonoids from ochna integerrima |
publishDate |
2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/22892 |
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1763489645272760320 |