Inhibition of malarial topoisomerase II in Plasmodium falciparum by antisense nanoparticles

• Main Authors: Florian Föger, Wilai Noonpakdee, Brigitta Loretz, Songwut Joojuntr, Willi Salvenmoser, Marlene Thaler, Andreas Bernkop-Schnürch
• Other Authors: Medizinische Universitat Innsbruck
• Format: Article
• Published: 2018
• Subjects: Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/23900
• Institution: Mahidol University

New effective antimalarial agents are urgently needed due to increasing drug resistance of Plasmodium falciparum. Phosphorothioate antisense oligodeoxynucleotides (ODNs) silencing of malarial topoisomerase II gene have shown to possess promising features as anti malarial agents. In order to improve...