Expression of β<sup>E</sup> and γ-globin genes in infants heterozygous for hemoglobin E and double heterozygous for hemoglobin E and α-thalassemia

Expression of β<sup>E</sup> and γ-globin genes in infants heterozygous for hemoglobin E and double heterozygous for hemoglobin E and α-thalassemia

This study described the expression of βE-globin in newborns heterozygous for HbE. Despite the lower level of HbE, the pattern of βE-globin gene expression was similar to βA- globin because the increase in HbE and HbA reached the peak level at the same time. A delayed decline of HbF was observed.

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Bibliographic Details
Main Authors: Pranee Winichagoon, Saovaros Svasti, Pattanee Winichagoon, Chureeporn Chitchumroonchokchai, Suthat Fucharoen
Other Authors: The Institute of Science and Technology for Research and Development, Mahidol University
Format: Article
Published: 2018
Subjects:
Medicine
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/24892
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Institution: Mahidol University
Description
Summary:This study described the expression of βE-globin in newborns heterozygous for HbE. Despite the lower level of HbE, the pattern of βE-globin gene expression was similar to βA- globin because the increase in HbE and HbA reached the peak level at the same time. A delayed decline of HbF was observed.

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