Independent evolution of pyrimethamine resistance in Plasmodium falciparum isolates in Melanesia

Independent evolution of pyrimethamine resistance in Plasmodium falciparum isolates in Melanesia

Pyrimethamine resistance in Plasmodium falciparum has previously been shown to have emerged once in Southeast Asia, from where it spread to Africa. Pyrimethamine resistance in this parasite is known to be conferred by mutations in the gene encoding dihydrofolate reductase (dhfr). We have analyzed po...

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Bibliographic Details
Main Authors: Toshihiro Mita, Kazuyuki Tanabe, Nobuyuki Takahashi, Takahiro Tsukahara, Hideaki Eto, Lek Dysoley, Hiroshi Ohmae, Kiyoshi Kita, Srivicha Krudsood, Sornchai Looareesuwan, Akira Kaneko, Anders Björkman, Takatoshi Kobayakawa
Other Authors: Tokyo Women's Medical University
Format: Article
Published: 2018
Subjects:
Medicine
Pharmacology, Toxicology and Pharmaceutics
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/24982
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Institution: Mahidol University

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https://repository.li.mahidol.ac.th/handle/123456789/24982

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