A new antimycobacterial, 3β-acetoxy-15α,22-dihydroxyhopane, from the insect pathogenic fungus Aschersonia tubulata

Bioassay-guided fractionation of the cell extract of the insect pathogenic fungus Aschersonia tubulata BCC 1785 led to the isolation of dustanin (1), 3β,15α,22-trihydroxyhopane (3), 5α,8α-epidioxy-24(R)-methylcholesta-6,22-diene-3β-ol (6), together with the new 3β-acetoxy-15α,22-dihydroxyhopane (4)....

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Main Authors:	S. Boonphong, P. Kittakoop, M. Isaka, P. Palittapongarnpim, A. Jaturapat, K. Danwisetkanjana, M. Tanticharoen, Y. Thebtaranonth
Other Authors:	Naresuan University
Format:	Article
Published:	2018
Subjects:	Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics
Online Access:	https://repository.li.mahidol.ac.th/handle/123456789/26465
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Institution:	Mahidol University

id	th-mahidol.26465
record_format	dspace
spelling	th-mahidol.264652018-09-07T16:53:40Z A new antimycobacterial, 3β-acetoxy-15α,22-dihydroxyhopane, from the insect pathogenic fungus Aschersonia tubulata S. Boonphong P. Kittakoop M. Isaka P. Palittapongarnpim A. Jaturapat K. Danwisetkanjana M. Tanticharoen Y. Thebtaranonth Naresuan University Thailand National Center for Genetic Engineering and Biotechnology Mahidol University Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics Bioassay-guided fractionation of the cell extract of the insect pathogenic fungus Aschersonia tubulata BCC 1785 led to the isolation of dustanin (1), 3β,15α,22-trihydroxyhopane (3), 5α,8α-epidioxy-24(R)-methylcholesta-6,22-diene-3β-ol (6), together with the new 3β-acetoxy-15α,22-dihydroxyhopane (4). Chemical structures of these compounds were elucidated by spectral analyses as well as chemical transformation. Compounds I and 4 exhibited antimycobacterial activity with the minimum inhibitory concentration (MIC) of 12:5 μg/ml. 2018-09-07T09:38:11Z 2018-09-07T09:38:11Z 2001-04-26 Article Planta Medica. Vol.67, No.3 (2001), 279-281 10.1055/s-2001-11997 00320943 2-s2.0-0035053787 https://repository.li.mahidol.ac.th/handle/123456789/26465 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0035053787&origin=inward
institution	Mahidol University
building	Mahidol University Library
continent	Asia
country	Thailand Thailand
content_provider	Mahidol University Library
collection	Mahidol University Institutional Repository
topic	Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics
spellingShingle	Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics S. Boonphong P. Kittakoop M. Isaka P. Palittapongarnpim A. Jaturapat K. Danwisetkanjana M. Tanticharoen Y. Thebtaranonth A new antimycobacterial, 3β-acetoxy-15α,22-dihydroxyhopane, from the insect pathogenic fungus Aschersonia tubulata
description	Bioassay-guided fractionation of the cell extract of the insect pathogenic fungus Aschersonia tubulata BCC 1785 led to the isolation of dustanin (1), 3β,15α,22-trihydroxyhopane (3), 5α,8α-epidioxy-24(R)-methylcholesta-6,22-diene-3β-ol (6), together with the new 3β-acetoxy-15α,22-dihydroxyhopane (4). Chemical structures of these compounds were elucidated by spectral analyses as well as chemical transformation. Compounds I and 4 exhibited antimycobacterial activity with the minimum inhibitory concentration (MIC) of 12:5 μg/ml.
author2	Naresuan University
author_facet	Naresuan University S. Boonphong P. Kittakoop M. Isaka P. Palittapongarnpim A. Jaturapat K. Danwisetkanjana M. Tanticharoen Y. Thebtaranonth
format	Article
author	S. Boonphong P. Kittakoop M. Isaka P. Palittapongarnpim A. Jaturapat K. Danwisetkanjana M. Tanticharoen Y. Thebtaranonth
author_sort	S. Boonphong
title	A new antimycobacterial, 3β-acetoxy-15α,22-dihydroxyhopane, from the insect pathogenic fungus Aschersonia tubulata
title_short	A new antimycobacterial, 3β-acetoxy-15α,22-dihydroxyhopane, from the insect pathogenic fungus Aschersonia tubulata
title_full	A new antimycobacterial, 3β-acetoxy-15α,22-dihydroxyhopane, from the insect pathogenic fungus Aschersonia tubulata
title_fullStr	A new antimycobacterial, 3β-acetoxy-15α,22-dihydroxyhopane, from the insect pathogenic fungus Aschersonia tubulata
title_full_unstemmed	A new antimycobacterial, 3β-acetoxy-15α,22-dihydroxyhopane, from the insect pathogenic fungus Aschersonia tubulata
title_sort	new antimycobacterial, 3β-acetoxy-15α,22-dihydroxyhopane, from the insect pathogenic fungus aschersonia tubulata
publishDate	2018
url	https://repository.li.mahidol.ac.th/handle/123456789/26465
_version_	1763496351518162944

A new antimycobacterial, 3β-acetoxy-15α,22-dihydroxyhopane, from the insect pathogenic fungus Aschersonia tubulata

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