Mechanism of HMGB1 release inhibition from RAW264.7 cells by oleanolic acid in Prunus mume Sieb. et Zucc

• Main Authors: Ko Ichi Kawahara, Teruto Hashiguchi, Kazuo Masuda, Abbi R. Saniabadi, Kiyoshi Kikuchi, Salunya Tancharoen, Takashi Ito, Naoki Miura, Yoko Morimoto, Kamal K. Biswas, Yuko Nawa, Xiaojie Meng, Yoko Oyama, Kazunori Takenouchi, Binita Shrestha, Hisayo Sameshima, Toshiaki Shimizu, Taro Adachi, Masakazu Adachi, Ikuro Maruyama
• Other Authors: Kagoshima University Faculty of Medicine
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/27343
• Institution: Mahidol University

High mobility group box-1 protein (HMGB1), primarily from the nucleus, is released into the extracellular milieu either passively from necrotic cells or actively through secretion by monocytes/macrophages. Extracellular HMGB1 acts as a potent inflammatory agent by promoting the release of cytokines...