Enhancement of cell-mediated immune response in mice by whole HIV-1 gag in mycobacterium bovis BCG as a live vaccine candidate

• Main Authors: Duanthanorm Promkhatkaew, Nadthanan Pinyosukhee, Wilai Thongdeejaroen, Reungpung Sutthent, Pathom Sawanpanyalert, Paijit Warachit
• Other Authors: Thailand Ministry of Public Health
• Format: Article
• Published: 2018
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/28261
• Institution: Mahidol University

In this study, we employed a recombinant Mycobacterium bovis Bacille Calmette-Guerin (BCG) harboring whole HIV-1 CRF01-AE gag DNA as a candidate vaccine to investigate specific cell-mediated immunity in BALB/c mice. Construction of the stable expression recombinant BCG was achieved by demonstrating...