The aspergillus fumigatus p-type golgi apparatus Ca2+/Mn2+ ATPase pmra is involved in cation homeostasis and cell wall integrity but is not essential for pathogenesis

The aspergillus fumigatus p-type golgi apparatus Ca2+/Mn2+ ATPase pmra is involved in cation homeostasis and cell wall integrity but is not essential for pathogenesis

The Aspergillus fumigatus δpmrA (Golgi apparatus Ca2+/Mn2+ P-type ATPase) strain has osmotically suppressible basal growth defects and cationic tolerance associated with increased expression of calcineurin pathway genes. Despite increased β-glucan and chitin content, it is hypersensitive to cell wal...

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Bibliographic Details
Main Authors: Nadthanan Pinchai, Praveen Rao Juvvadi, Jarrod R. Fortwendel, B. Zachary Perfect, Luise E. Rogg, Yohannes G. Asfaw, William J. Steinbach
Other Authors: Duke University School of Medicine
Format: Note
Published: 2018
Subjects:
Biochemistry, Genetics and Molecular Biology
Immunology and Microbiology
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/28774
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Institution: Mahidol University
Description
Summary:The Aspergillus fumigatus δpmrA (Golgi apparatus Ca2+/Mn2+ P-type ATPase) strain has osmotically suppressible basal growth defects and cationic tolerance associated with increased expression of calcineurin pathway genes. Despite increased β-glucan and chitin content, it is hypersensitive to cell wall inhibitors but remains virulent, suggesting a role for PmrA in cation homeostasis and cell wall integrity. © 2010, American Society for Microbiology. All Rights Reserved.

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