The aspergillus fumigatus p-type golgi apparatus Ca2+/Mn2+ ATPase pmra is involved in cation homeostasis and cell wall integrity but is not essential for pathogenesis

• Main Authors: Nadthanan Pinchai, Praveen Rao Juvvadi, Jarrod R. Fortwendel, B. Zachary Perfect, Luise E. Rogg, Yohannes G. Asfaw, William J. Steinbach
• Other Authors: Duke University School of Medicine
• Format: Note
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/28774
• Institution: Mahidol University

The Aspergillus fumigatus δpmrA (Golgi apparatus Ca2+/Mn2+ P-type ATPase) strain has osmotically suppressible basal growth defects and cationic tolerance associated with increased expression of calcineurin pathway genes. Despite increased β-glucan and chitin content, it is hypersensitive to cell wal...