The role of previously unmeasured organic acids in the pathogenesis of severe malaria

• Main Authors: Herdman, M. Trent, Natthida Sriboonvorakul, Leopold, Stije J., Sam Douthwaite, Sanjib Mohanty, M. Mahtab Uddin Hassan, Maude, Richard J., Kingston, Hugh WF, Katherine Plewes, Prakaykaew Charunwatthana, Kamolrat Silamut, Woodrow, Charles J., Kesinee Chotinavich, Hossain, Md. Amir, Faiz, M. Abul, Saroj Mishra, Natchanun Leepipatpiboon, White, Nicholas J., Day, Nicholas PJ, Joel Tarning, Dondorp, Arjen M.
• Other Authors: Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit
• Format: Article
• Language: English
• Published: 2017
• Subjects: Open Access article; organic acids; Malaria
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/3089
• Institution: Mahidol University

Introduction: Severe falciparum malaria is commonly complicated by metabolic acidosis. Together with lactic acid (LA), other previously unmeasured acids have been implicated in the pathogenesis of falciparum malaria. Methods: In this prospective study, we characterised organic acids in adults with...