Cross-protective capacity of Japanese encephalitis (JE) vaccines against circulating heterologous JE virus genotypes

Current Japanese encephalitis vaccines are derived from strains of genotype III, yet heterologous genotypes are emerging in endemic areas. Inactivated vaccines given to European travelers were found to elicit protective levels of neutralizing antibodies against heterologous strains of genotypes I-IV...

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Bibliographic Details
Main Authors: Elina O. Erra, Helena Hervius Askling, Sutee Yoksan, Lars Rombo, Jukka Riutta, Sirkka Vene, Lars Lindquist, Olli Vapalahti, Anu Kantele
Other Authors: University of Helsinki Haartman Institute
Format: Article
Published: 2018
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/32572
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Institution: Mahidol University
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Summary:Current Japanese encephalitis vaccines are derived from strains of genotype III, yet heterologous genotypes are emerging in endemic areas. Inactivated vaccines given to European travelers were found to elicit protective levels of neutralizing antibodies against heterologous strains of genotypes I-IV. © 2012 The Author. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.