Ex-Vivo cytoadherence phenotypes of Plasmodium falciparum strains from Malian children with hemoglobins A, S, and C

• Main Authors: Jeanette T. Beaudry, Michael A. Krause, Seidina A S Diakite, Michael P. Fay, Gyan Joshi, Mahamadou Diakite, Nicholas J. White, Rick M. Fairhurst
• Other Authors: National Institute of Allergy and Infectious Diseases
• Format: Article
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/33034
• Institution: Mahidol University

Sickle hemoglobin (Hb) S and HbC may protect against malaria by reducing the expression of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) on the surface of parasitized red blood cells (RBCs), thereby weakening their cytoadherence to microvascular endothelial cells (MVECs) and impairin...