A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains
Malaria is a major public health problem that is actively being addressed in a global eradication campaign. Increased population mobility through international air travel has elevated the risk of re-introducing parasites to elimination areas and dispersing drug-resistant parasites to new regions. A...
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th-mahidol.332562018-11-09T10:13:55Z A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains Mark D. Preston Susana Campino Samuel A. Assefa Diego F. Echeverry Harold Ocholla Alfred Amambua-Ngwa Lindsay B. Stewart David J. Conway Steffen Borrmann Pascal Michon Issaka Zongo Jean Bosco Ouédraogo Abdoulaye A. Djimde Ogobara K. Doumbo Francois Nosten Arnab Pain Teun Bousema Chris J. Drakeley Rick M. Fairhurst Colin J. Sutherland Cally Roper Taane G. Clark London School of Hygiene & Tropical Medicine Wellcome Trust Sanger Institute Purdue University International Center for Medical Research and Training University of Malawi Malawi-Liverpool-Wellcome Trust Clinical Research Programme Liverpool School of Tropical Medicine Medical Research Council Laboratories Gambia Wellcome Trust Research Laboratories Nairobi Universitat Tubingen Divine Word University Institut de Recherche en Sciences de la Santé University of Bamako Faculty of Medicine, Pharmacy and Odonto-Stomatology Nuffield Department of Clinical Medicine Mahidol University King Abdullah University of Science and Technology National Institutes of Health, Bethesda Biochemistry, Genetics and Molecular Biology Chemistry Physics and Astronomy Malaria is a major public health problem that is actively being addressed in a global eradication campaign. Increased population mobility through international air travel has elevated the risk of re-introducing parasites to elimination areas and dispersing drug-resistant parasites to new regions. A simple genetic marker that quickly and accurately identifies the geographic origin of infections would be a valuable public health tool for locating the source of imported outbreaks. Here we analyse the mitochondrion and apicoplast genomes of 711 Plasmodium falciparum isolates from 14 countries, and find evidence that they are non-recombining and co-inherited. The high degree of linkage produces a panel of relatively few single-nucleotide polymorphisms (SNPs) that is geographically informative. We design a 23-SNP barcode that is highly predictive (∼92%) and easily adapted to aid case management in the field and survey parasite migration worldwide. © 2014 Macmillan Publishers Limited. All rights reserved. 2018-11-09T01:52:11Z 2018-11-09T01:52:11Z 2014-06-13 Article Nature Communications. Vol.5, (2014) 10.1038/ncomms5052 20411723 2-s2.0-84902504071 https://repository.li.mahidol.ac.th/handle/123456789/33256 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84902504071&origin=inward |
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Biochemistry, Genetics and Molecular Biology Chemistry Physics and Astronomy Mark D. Preston Susana Campino Samuel A. Assefa Diego F. Echeverry Harold Ocholla Alfred Amambua-Ngwa Lindsay B. Stewart David J. Conway Steffen Borrmann Pascal Michon Issaka Zongo Jean Bosco Ouédraogo Abdoulaye A. Djimde Ogobara K. Doumbo Francois Nosten Arnab Pain Teun Bousema Chris J. Drakeley Rick M. Fairhurst Colin J. Sutherland Cally Roper Taane G. Clark A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains |
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Malaria is a major public health problem that is actively being addressed in a global eradication campaign. Increased population mobility through international air travel has elevated the risk of re-introducing parasites to elimination areas and dispersing drug-resistant parasites to new regions. A simple genetic marker that quickly and accurately identifies the geographic origin of infections would be a valuable public health tool for locating the source of imported outbreaks. Here we analyse the mitochondrion and apicoplast genomes of 711 Plasmodium falciparum isolates from 14 countries, and find evidence that they are non-recombining and co-inherited. The high degree of linkage produces a panel of relatively few single-nucleotide polymorphisms (SNPs) that is geographically informative. We design a 23-SNP barcode that is highly predictive (∼92%) and easily adapted to aid case management in the field and survey parasite migration worldwide. © 2014 Macmillan Publishers Limited. All rights reserved. |
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London School of Hygiene & Tropical Medicine |
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London School of Hygiene & Tropical Medicine Mark D. Preston Susana Campino Samuel A. Assefa Diego F. Echeverry Harold Ocholla Alfred Amambua-Ngwa Lindsay B. Stewart David J. Conway Steffen Borrmann Pascal Michon Issaka Zongo Jean Bosco Ouédraogo Abdoulaye A. Djimde Ogobara K. Doumbo Francois Nosten Arnab Pain Teun Bousema Chris J. Drakeley Rick M. Fairhurst Colin J. Sutherland Cally Roper Taane G. Clark |
format |
Article |
author |
Mark D. Preston Susana Campino Samuel A. Assefa Diego F. Echeverry Harold Ocholla Alfred Amambua-Ngwa Lindsay B. Stewart David J. Conway Steffen Borrmann Pascal Michon Issaka Zongo Jean Bosco Ouédraogo Abdoulaye A. Djimde Ogobara K. Doumbo Francois Nosten Arnab Pain Teun Bousema Chris J. Drakeley Rick M. Fairhurst Colin J. Sutherland Cally Roper Taane G. Clark |
author_sort |
Mark D. Preston |
title |
A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains |
title_short |
A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains |
title_full |
A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains |
title_fullStr |
A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains |
title_full_unstemmed |
A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains |
title_sort |
barcode of organellar genome polymorphisms identifies the geographic origin of plasmodium falciparum strains |
publishDate |
2018 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/33256 |
_version_ |
1763489134592131072 |