Peptide-based delivery of oligonucleotides across blood-brain barrier model

• Main Authors: Artita Srimanee, Jakob Regberg, Mattias Hallbrink, Kaido Kurrikoff, Kadi Liis Veiman, Opa Vajragupta, Ülo Langel
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemical Engineering; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/33458

Delivery of pharmaceutical agents across a blood-brain barrier (BBB) is a challenge for brain cancer therapy. In this study, an in vitro BBB model was utilized to study the delivery of oligonucleotides across brain endothelial cells targeting to glioma cells in a Transwell™ setup. A series of novel...